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Introduction Mycobacterium leprae the causative agent of lep
2020-01-07
Introduction Mycobacterium leprae, the causative agent of leprosy, affects skin, peripheral nerves and upper respiratory tract [1]. Although leprosy has been eradicated from most of the countries, it still affects approximately a quarter of a million people from India [2]. Details of many bacteriol
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To determine direct DDR binding partners
2020-01-07
To determine direct DDR1-binding partners and to further connect to Akt and mTOR signaling, we performed mass spectrometry on DDR1 immunoprecipitates and found various candidates of the Akt and mTOR pathway such as LARP1 (La-related protein 1) and RPS6 (40S ribosomal protein S6/ S6). Most intriguing
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Early VL diagnosis makes it possible to formulate a
2020-01-06
Early VL diagnosis makes it possible to formulate a quicker and more effective treatment against the disease, which could increase the possibility of a cure for the patients, as well as reduce the toxicity of the drugs (Coelho et al., 2009); however, conventional and molecular parasitological method
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The rate of protein degradation is often
2020-01-06
The rate of protein degradation is often affected by N-starvation [12], therefore, we examined the influence of N-starvation against the appearance of CEPs. N-starved cucumber cotyledons contained less amounts of protein and Rubisco, but the temporal changes in protein and Rubisco contents were simi
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br Introduction Increasing investigations show that the eart
2020-01-06
Introduction Increasing investigations show that the earthworm extract has various beneficial pharmacological activities, including fibrinolytic [2] and anticoagulative activity [3], anti-inflammatory activity [4], anti-oxidative activity [5], [6], peripheral nerve regeneration [7], bone regenera
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This pre GC B cell differentiation deficiency
2020-01-06
This pre-GC B cell differentiation deficiency caused by RD2 loss of function was explained at least in part by the finding that the BCL6 RD2 domain is required to repress expression of the key migration factors GRP183 and S1PR1. Downregulation of GRP183 is critically important for B cell migration i
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Emi protein consists of an N terminal regulatory region
2020-01-06
Emi2 protein consists of an N-terminal regulatory region and a C-terminal functional region. The C-terminal region contains a destruction box (D-box), which likely competes with APC/C substrates (including cyclin B) for APC/C binding, and a zinc-binding region (ZBR), which somehow inhibits APC/C ubi
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Introduction Cholesterol plays a pivotal role as a constitue
2020-01-06
Introduction Cholesterol plays a pivotal role as a constituent of biological membranes and as a precursor for vitamins, hormones and bile acids. Accordingly, its production, distribution, and elimination must be tightly regulated at the cellular and organismal level. Accordingly, dysregulated chole
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br Methods br Results br Discussion Preclinical data
2020-01-06
Methods Results Discussion Preclinical data indicate that nepicastat modulates sympathetic drive to the mct2 pathway with a mild pressor effect in various animal models of hypertension (Stanney et al., 1998). However in this clinical study, the doses of nepicastat employed did not significa
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The CYP D inferred metabolizer phenotype describes
2020-01-06
The CYP2D6-inferred metabolizer phenotype describes only one phase of the tramadol (T) ADME (absorption, distribution, metabolism, and excretion) and response process and does not explain all genotypic contribution of an individual’s phenotypic expression [11]. Numerous polymorphisms in the downstre
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br Materials and methods br Results and discussion Iron
2020-01-06
Materials and methods Results and discussion Iron (II)/2-oxoglutarate (2-OG)-dependent oxygenases [28], [29] catalyze oxidative reactions of a range of metabolic processes including the hydroxylation of l-proline and l-lysine residues during the post-translational modification of collagen. Mor
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The oxidation of the lipid fraction
2020-01-06
The oxidation of the lipid fraction of meat is an extremely complex process because of the high sensitivity of oxidation products to decomposition, their reactions with other components, the complex effect of catalysts and the presence of antioxidants. These changes are the main cause of limited she
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It has been reported that
2020-01-06
It has been reported that PGE2 increases expression of the survivin mRNA (Baratelli et al. 2005) and promotes the stabilization of the survivin protein in some tumor STF 083010 (Krysan et al. 2003). However, it is unclear whether PGE2 affects the expression of survivin mRNA or promotes the stabiliz
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br Conclusion In this study we investigated functional
2020-01-06
Conclusion In this study, we investigated functional alterations of ECs following exposure to mechanical and/or physicochemical stimuli. Specifically, hypoxia induced phosphorylation with significant increases after 30 min and the maximum increase was after 180 min. Our data show that a combinati
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br Materials and methods br Results br Discussion Approximat
2020-01-06
Materials and methods Results Discussion Approximately 90% of pulmonary emphysema causes are related to smoking and its progression in patients and are characterized by severity levels [5]. Experimental models using CS to induce emphysema are widely used because they resemble the emphysema
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