• PGR regulation of epithelium stroma crosstalk is proven

  2023-01-30

  

  PGR regulation of epithelium–stroma crosstalk is proven by numerous studies that utilize genetically engineered mouse models. Before embryo implantation, epithelial PGR mediates the progesterone signal to transcriptionally increase the Ihh levels 13, 15. Epithelial IHH then activates the stromal hed

• br Implications for cancer ROS have

  2023-01-30

  

  Implications for cancer ROS have a long history of being involved in the development and progression of cancer and increased ROS level is considered as a hallmark of many tumors [76], [77]. Initially, it was thought that ROS would serve as chemical mutagens that would indiscriminately damage cell

• WEHI-539 hydrochloride As regards LEPR Sun et al showed

  2023-01-30

  

  As regards LEPR, Sun et al. showed that the rs1137101-223A > G polymorphism influences the effectiveness of simvastatin on plasma HDL-C levels in CHD patients [35]. In accordance with the results of García-Bermúdez et al., however, no such an association exists between leptin rs2167270 (G > A) polym

• Over the years measures of total antioxidant status TAS

  2023-01-30

  

  Over the years, measures of total antioxidant status (TAS) have been developed to capture the collective effect of antioxidant defense capacity, including enzymatic and nonenzymatic systems (Fraga et al., 2014, Franco et al., 2007). Multiple antioxidant enzymes, as well as antioxidant vitamins and m

• br Antibiotic drug discovery approaches Traditionally novel

  2023-01-30

  

  Antibiotic drug discovery approaches Traditionally, novel NHS-12-Biotin were largely discovered by phenotypic screening approaches of various sources of compounds, such as natural products isolated from extracts of soil microbes and semi-synthetic or fully synthetic compound libraries derived fro

• A phase I trial has recently evaluated enzalutamide

  2023-01-29

  

  A phase I trial has recently evaluated enzalutamide, an anti-androgen agent, in patients with ER- and AR-positive advanced BC to estimate safety and tolerability of enzalutamide therapy alone or in association to anastrozole, exemestane or fulvestrant [65]. The results of major clinical trials with

• br Acknowledgement Work in the McEwan Laboratory is funded b

  2023-01-29

  

  Acknowledgement Work in the McEwan Laboratory is funded by the Chief Scientist Office of Scottish Government: Grants ETM-258 and ETM-382. BE is supported by an Erasmus scholarship (D -JENA01). Introduction The equine placenta is a noninvasive transient organ, classified as diffuse and epithel

• Another important finding of our study

  2023-01-29

  

  Another important finding of our study is the observation that high glucose per se does not affect TER in mature HREC monolayers; but at the same time it does upregulate ICAM-1 directly and activates HRECs to leukocyte adhesion. This would imply that high glucose affects TER in mature HREC monolayer

• There are two ways to transport FFAs

  2023-01-29

  

  There are two ways to transport FFAs into cells. First by passive diffusion. Second as the putative long-chain fatty funding systems transporters are proposed, CD36 the plasma membrane-associated fatty acid-binding protein (FABPpm) and fatty acid transport proteins (FATP) [11], where CD36 is respon

• br Theoretical mechanism of ABCA activity in LE LY

  2023-01-29

  

  Theoretical mechanism of ABCA2 activity in LE/LY in modulation of cholesterol trafficking It is important to confirm that ABCA2 is a lipid transporter and identify the substrates that are mechanistic in its cholesterol sequestering activity. We hypothesize that ABCA2 modulates cholesterol sequest

• Application of the broad acting HTR antagonist methiothepin

  2023-01-29

  

  Application of the broad-acting 5-HTR antagonist methiothepin (Bard et al., 1996, Hoyer et al., 1994, Peroutka, 1990) converted the TBS-induced response of both thalamocortical and intracortical A1 synapses from LTP to LTD, an effect that was mimicked by the selective 5-HT2R antagonist ketanserin (L

• Introduction hydroxytryptamine HT is found throughout the bo

  2023-01-29

  

  Introduction 5-hydroxytryptamine (5-HT) is found throughout the body and influences smooth muscle activity in various tissues including the intestine, vasculature and urinary PYR-41 (Kim and Camilleri, 2000, Klarskov and Horby-Petersen, 1986, Mohammad-Zadeh et al., 2008). The current classificatio

• Patients with ADA SCID may experience autoimmune AEs

  2023-01-29

  

  Patients with ADA-SCID may experience autoimmune AEs after SCT (and/or during ERT) that are thought to be related to immune dysregulation prior to achieving complete immune reconstitution. The more common autoimmune manifestations include hemolytic anemia, hypothyroidism, and immune thrombocytopenia

• Several reports of single cases of MG patients treated

  2023-01-29

  

  Several reports of single cases of MG patients treated with Rituximab have claimed a favourable response (Baek et al., 2007, Gajra et al., 2004, Hain et al., 2006, Thakre et al., 2007, Wylam et al., 2003, Zaja et al., 2000). We report our experience with Rituximab in 6 patients with severe MG, 3 pa

• The main function of ATR

  2023-01-29

  

  The main function of ATR/CHK1 signaling is activating 17 aag checkpoint arrest for S and G2 phases in mammalian cells. There are three checkpoints in response to DNA damage: G1/S, G2/M, and S-phase. The G2/M checkpoint can prevent cells that incur DNA damage in G2 phase or progress into G2 phase fro

15417 records 363/1028 page Previous Next First page 上5页 361362363364365 下5页 Last page